办公地址： 生命科学学院A209
个人主页：
工作经历：
2009.05- 南京大学生命科学学院，博士研究生导师
2007.12- 南京大学生命科学学院，教授
2006.09-2007.12 南京大学生命科学学院，副教授
2002.12-2006.04 美国康奈尔大学，博士后(导师：Dr. Li Li)
2001.09-2002.11 德国马普化学生态所，博士后(导师：Dr. Jonathan Gershenzon院士)
1998.12-2001.09 中科院上海植物生理生态研究所，博士后(导师：陈晓亚院士)
1998.02-1998.10 美国康涅狄克大学，访问学者(导师：Dr. Charles Yarish)
1997.02-1998.12 中科院海洋所，博士后(导师：曾呈奎院士、费修绠研究员)
学习经历：
1994.09-1997.01 南京大学生物学系，植物学专业，博士研究生，导师：刘志礼教授
1991.07-1994.09 南京大学生物学系，植物学专业，硕士研究生，导师：陈晓亚副教授
1987.09-1991.07 南京大学生物学系，植物学专业，本科生
本实验室利用分子生物学手段研究与植物叶綠体发育相关的代谢过程及其调控机制。
牻牛儿基牻牛儿基二磷酸(GGPP)是植物萜类代谢途径中的一个关键分支点。植物以GGPP为底物，合成大约2万种天然产物，其中包括激素(赤霉素、脱落酸、独脚金内酯)、色素(类胡萝卜素和叶绿素的植基侧链)、维生素(来自胡萝卜素的维生素A和维生素E的植基侧链)，以及参与植物对病原微生物防御机制的二萜植保素。这些代谢分支共同竞争GGPP，构成了牵一发而动全身的复杂网络。GGPP的合成及其在下游分支间的分配机制影响了植物的生长发育和逆境适应能力，也影响着农产品的营养品质和风味特色，以及园艺植物的观赏价值。
本实验室近年来围绕这一核心问题开展了一系列研究工作，相关成果发表于PNAS (2017)、Plant Cell (2019, 2023)、Molecular Plant (2021)、Plant Biotechnology Journal (2021)等重要学术刊物。主要进展包括：
1. 解析了水稻中GGPP保障叶绿素代谢的调控机制(Zhou et al., 2017, PNAS)[南京大学优秀博士学位论文]；
2. 解析了植物GPP合酶的起源与功能分化，并发现了决定GGPPS/GPPS产物链长的分子机制(Song et al., 2023, Plant Cell)[南京大学优秀博士学位论文]。
在蓝细菌和藻类植物中，GGPPS通常只能专一地合成GGPP。随着在苔藓植物中的基因家族扩张，一些GGPPS逐渐产生了合成GPP的能力，而这一能力在蕨类植物中得到发展，并最终形成裸子植物中功能专一的GPPS。与此同时，在苔藓植物中还出现了由GGPPS向无催化功能的小亚基蛋白的分化。该分化首先在蕨类和裸子植物中形成了对GGPPS酶活具有促进能力的II类小亚基(SSUII)，并最终在被子植物中产生了能够改变GGPPS用于合成GPP的I类小亚基(SSUI)。利用GGPPS-SSUI组合取代单一的GPPS来产生GPP，在保障GGPPS功能(植物的生长和发育)的前提下，赋予了被子植物萜类代谢更大的自由度。
3. 解析了锌指蛋白ORANGE在子叶中通过转录因子TCP14对叶绿素合成和叶绿体发育的抑制作用(Sun et al., 2019, Plant Cell)；
4. 建立了植物基因组无缺组装的新技术路线(Li et al., 2021. Molecular Plant)[南京大学优秀博士学位论文][江苏省自然科学百篇优秀学术成果论文(2024)]
5. 解析了辣椒果实中类胡萝卜素合成的部分代谢流调控机制(Wang et al., 2018, 219, J Agric Food Chem)；
6. 以紫菜为主要材料，系统研究了红藻的类胡萝卜素代谢途径，初步揭示了这一重要代谢途径在植物中的早期演化(Yang et al., 2014, J Intergr Plant Biol; 2015, J Appl Phycol; Cao et al., 2017, Mar Drugs; Deng et al., 2020, J Agric Food Chem)。
7. 建立了基于蓝细菌的类胡萝卜素代谢酶活鉴定系统和合成生物学光驱动底盘(Cao et al., 2020, Plant Biotechnol J)。
学会任职：
中国海洋湖沼学会藻类学分会: 副理事长 (2007-2024)
中国植物生理与植物分子生物学学会：理事(2014-2024)
江苏省植物生理学会：副理事长(2015-2024)
American Association for the Advancement of Science: 会员 (2003-)
American Society of Plant Biologists: 会员 (2003-)
审稿人：
Nature Plants, Nature Communications, Plant Cell, Molecular Plant, Plant Physiology, Plant Journal, Plant Biotechnology Journal, Metabolic Engineering, New Phytologist, Trends in Plant Science, Plant Cell Physiology, Plant Cell & Environment, Journal of Integrative Plant Biology等
研究论文(*为通讯作者)：
2026.
2025.
2024.
2023
2022
2021
2020
2019
2018
2017
2016
2015
2014
2. Zhang W-G, Liu M, Zhang P-L, Yu F-G, Lu S, Li P-F*, Zhou J-Y. 2014. Effects of Paraquat on photosynthetic pigments, antioxidant enzymes, and gene expression in Chlorella pyrenoidosa under mixotrophic compared with autotrophic conditions. Archives of Environmental Contamination and Toxicology 67: 593-600.
3. Zhang W-G, Zhang P-L, Sun H, Chen MZ, Lu S, Li PF*. 2014. Effects of various organic carbon sources on the growth and biochemical composition of Chlorella pyrenoidosa. Bioresource Technology 173: 52-58.
2013
2. Xie X, Gu W, Gao S, Lu S, Li J, Pang G, Wang G*, Shen S*. 2013. Alternative electron transports participate in the maintenance of violaxanthin de-epoxidase activity of Ulva sp. under low irradiance. PLoS ONE 8: e78211.
2012
1. Li L*, Yang Y, Xu Q, Owsiany K, Welsch R, Chitchumroonchokchai C, Lu S, van Eck J, Deng XX, Faila M, Thannjaiser T. 2012. The Or gene enhances carotenoid accumulation and stability during post-harvest storage of potato tubers. Molecular Plant 5: 339-352.
3. Li JL, Chen QQ, Jin QP, Gao J, Zhao PJ, Lu S, Zeng Y*. 2012. IeCPS2is potentially involved in the biosynthesis of pharmacologically active Isodon diterpenoids rather than gibberellin. Phytochemistry 76: 32-39.
4. Yuan T-T, Chen Q-Q, Zhao P-J, Zeng Y*, Liu XZ, Lu S. 2012. Identification of enzymes responsible for the reduction of geraniol to citronellol. Natural Products and Bioprospecting 1: 108-111.
2011
1. Lu S*, Yarish C. 2011. Interaction of photoperiod and temperature in the development of conchocelis of Porphyra purpurea (Rhodophyta: Bangiales). Journal of Applied Phycology 23: 89-96.
2. Zhou X-J, Sun T-H, Wang N, Ling H-Q, Lu S, Li L*. 2011. The cauliflower Orange gene enhances petiole elongation by suppressing expression of eukaryotic release factor 1. New Phytologist 190: 89-100.
2010
1. Sun T-H, Liu C-Q, Hui Y-Y, Wu W-K, Zhou Z-G, Lu S*. 2010. Coordinated regulation of gene expression for carotenoid metabolism in Chlamydomonas reinhardtii. Journal of Integrative Plant Biology 52: 868-878.
2. Yang C-Q, Lu S, Mao Y-B, Wang L-J, Chen X-Y*. 2010. Characterization of two NADPH: Cytochrome P450 reductases from cotton (Gossypium hirsutum). Phytochemistry 71: 27-35.
3. Li Y-Y, Shen S-D*, He L-H, Xu P, Lu S. 2010. Sequence analysis of rDNA intergenic spacer (IGS) of Porphyra haitanensis. Journal of Applied Phycology 22: 187-193.
2009
1. Chen L, Men X, Ma M-R, Li P-F*, Jiao Q-C, Lu S, Kong F-X, Wu S-C. 2009. Polysaccharide relase by Aphanothece halophytica inhibits cyanobacteria/clay flocculation. Journal of Phycology 46: 417-423.
2008
1. Lu S, Li L*. 2008. Carotenoid metabolism: Biosynthesis, regulation, and beyond. Journal of Integrative Plant Biology 50: 778-785.
2. Zhou W, Zhu J-Y, Shen S-D, Lu S, Wang J-F, Xu J-R, Xu P*. 2008. Observations on the division characterization of diploid nuclear in Porphyra (Bangiales, Rhodophyta). Journal of Applied Phycology 20: 991-999.
2007
1. Guan X-Y, Yu N, Shangguan X-X, Wang S, Lu S, Chen X-Y*. 2007. Arabidopsis trichome research sheds light on cotton fiber development mechanisms. Chinese Science Bulletin 52: 1734-1741.
2. Chen A-X, Lou Y-G, Mao Y-B, Lu S, Wang L-J, Chen X-Y*. 2007. Plant terpenoids: Biosynthesis and ecoligical functions. Journal of Integrative Plant Biology 49: 179-186.
2006
2. Mao Y-B, Lu S, Wang L-J, Chen X-Y*. 2006. Biosynthesis of gossypol in cotton. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources. 1: 049.
3. Li* L, Lu S, Cosman KM, Earle ED, Garvin DF, O'Neill J. 2006. β-Carotene accumulation induced by the cauliflower Orgene is not due to an increased capacity of biosynthesis. Phytochemistry 67: 1177-1184.
2003
1. Li L*, Lu S, O'Halloran DM, Garvin DF, Vrebalov J. 2003. High-resolution genetic and physical mapping of the cauliflower high-beta-carotene gene Or (Orange). Molecular Genetics and Genomics 270: 132-138.
2002
2. Zhou X-J, Lu S, Xu Y-H, Wang J-W, Chen X-Y*. 2002. A cotton cDNA (GaPR-10) encoding a pathogenesis-related 10 protein with in vitro ribonuclease activity. Plant Science 162: 629-636.
2000
1. Yu X-H, Zhu Y-Q, Lu S, Zhang T-Z, Chen X-Y*, Xu Z-H. 2000. A comparative analysis of a fuzzless-lintless mutant of Gosypium hirsutum L. cv. Xu-142. Science in China (Ser. C) 43: 623-630.
2. Zhou X-J, Wang L-S, Lin Z-P, Jia J-W, Lu S, Chu Z-Q, Chen X-Y*. 2000. Fusion expression of Raphanus sativus- antifungal protein 1 (Rs-AFP1) in Escherichia coli and its antifungal activity on Verticillium dahliae. Acta Botanica Sinica 42: 703-707.
1999
1. Jia JW, Crock J, Lu S, Croteau R, Chen XY*. 1999. (3R)-Linalool synthase from Artemisia annua L.: cDNA isolation, characterization, and wound induction. Archives of Biochemisty and Biophysics 372: 143-149.
2. Chopin T*, Yarish C, Wilkes R, Belyea E, Lu S, Mathieson A. 1999. Developing Porphyra/salmon integrated aquaculture for bioremediation and diversification of the aquaculture industry. Journal of Applied Phycology 11: 463-472.
1996
1. Lu S*, Zhang X-N, Li P-Y, Liu Z-L, Xia Z-H. 1996. A salt-induced chloroplast protein from Dunaliella salina (Chlorophyta). Journal of Phycology 32: 983-986.
专著章节：
1. Lu S. 2015. Plant Metabolic Network. In: Plant Metabolomics (Ed: Qi X-Q, Wang Y-L, Chen, X-Y). Springer. pp. 195-212.
2. Gantt E, Berg GM, Bhattacharya D, Blouin NA, Brodie JA, Chan CX, Collen J, Cunningham FX Jr, Gross J, Grossman AR, Karpowicz S, Kitade Y, Klein AS, Levine IA, Lin SJ, Lu S, Lynch M, Minocha SC, Muller K, Neefus CD, De Oliveira MC, Rymarquis L, Smith A, Stiller JW, Wu WK, Yarish C, Zhuang YY, Brawley SH. 2010. Porphyra : complex life history in a harsh environment. P. umbilicalis , an intertidal red alga for genomic analysis. In Cellular Origin, Life in Extreme Habitats and Astrobiology. Vol. 13. Red Algae in the Genomic Age. (Sechbach J, Chapman DJ eds.). Springer. pp. 130-148.
3. Van Eck J, Zhou XJ, Lu S, Li L. 2009. Modulation of carotenoid accumulation in transgenic potato by inducing chromoplast formation with enhanced sink strength. In: Metabolic Engineering of Plant Secondary Pathways (Ed.: Walker J). Humana Press. pp. 77-93.
4. 卢山，陈晓亚. 2012. 植物次生代谢。植物生理与分子生物学(第四版)(陈晓亚、薛红卫主编)。高等教育出版社. pp. 369-389
5. 卢山. 2011. 植物代谢网络。植物代谢组学(漆小泉、王玉兰、陈晓亚主编)。化学工业出版社. pp. 184-202
6. 陈晓亚，卢山. 2007. 植物次生代谢。植物生理与分子生物学(第三版)(陈晓亚、汤章城主编)。高等教育出版社. pp. 329-356
7. Lu S, Chen XY. 2005. Terpenoid metabolism in cotton and qiaohao (Artemisia annua). In: Advances in Plant Physiology (Ed.: Hemantaranjan A), Vol. 8. Pawan Kumar Scientific Publishers (India). pp. 265-292.
8. 费修绠, 王素娟, 卢山. 1998. 红藻类细胞工程育种和育苗. 海洋生物技术. 山东科技出版社. pp. 7-26.
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